Selected Publications


  1. Pajarillo E, Johnson J Jr, Kim J, Karki P, Son DS, Aschner M, Lee E (2018). 17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. 65:280-288. PMID: 29183790.
  2. Ignacio RMC, Dong YL, Kabir SM, Choi H, Lee ES, Wilson AJ, Beeghly-Fadiel A, Whalen MM, Son DS (2018). CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget. 9(11):9751-9765. PMID: 29515768
  3. Karki P, Hong P, Johnson J Jr, Pajarillo E, Son DS, Aschner M, Lee EY (2018). Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-κB Pathways. Mol Neurobiol. 55(6):5031-5046 PMID: 28812276.
  4. Johnson J Jr, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E (2018). Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 67:112-120. PMID: 29778792.
  5. Scarton L, Yoon S, Oh S, Agyare E, Trevino J, Han B, Lee E, Setiawan VW, Permuth JB, Schmittgen TD, Odedina FG, Wilkie DJ. Pancreatic Cancer Related Health Disparities: A Commentary. Cancers (Basel). 2018 Jul 18;10(7). PMID: 30021952
  6. Ignacio RMC, Gibbs CR, Lee ES, Son The TGFα-EGFR-Akt signaling axis plays a role in enhancing proinflammatory chemokines in triple-negative breast cancer cells. Oncotarget. 2018 Jun 29;9(50):29286-29303. PMID: 30034618
  7. Pratap Karki, James Johnson Jr, Deok-Soo Son, Michael Aschner and Eunsook Lee (2017). Transcriptional regulation of human transforming growth factor-α in astrocytes. Mol Neurobiol. 54(2):964-976. PMID: 26797516.
  8. Choi H, Ignacio RMC, Lee ES, Wilson AJ, Khabele D, Son DS (2017). Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-κB in Human Serous Ovarian Epithelial Tumors. Immune Network. 17(2):121-127. PMID: 28458624.
  9. Johnson J Jr, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. (2017). Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. NeuroToxicology. 64:230-239. PMID: 28610743.
  10. Lee E, Karki P, Johnson J Jr, Hong P, Aschner M (2017). Manganese Control of Glutamate Transporters’ Gene Expression. Adv Neurobiol. 16:1-12. PMID: 28828603.
  11. Choi H, Ignacio RMC, Lee ES, Roby KF, Terranova PF, Son DS (2017). Localization of Serum Amyloid A3 in the Mouse Ovary. Immune Netw. 17(4):261-268. PMID: 28860955.
  12. Ignacio RM, Kabir SM, Lee ES, Adunyah SE, Son NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression. PLoS One. 2016;11(10):e0164189. PMID: 27723802
  13. Rosa Mistica C. Ignacio, Carla R. Gibbs, Lee E, Deok-Soo Son (2016). Differential chemokine signature between human preadipocytes and adipocytes. Immune Network. 16(3):189-94. PMID: 27340388.
  14. Rosa Mistica C. Ignacio, Syeda M. Kabir, Lee E, Samuel E. Adunyah, Deok-Soo Son (2016). Involvement of NF-kB-mediated CCL20 in CXCR2-driven ovarian cancer progression. PLoS One. 11(10): e0164189. PMID: 27723802.
  15. Karki P, Smith K, Johnson Jr. J, Aschner M and Lee E (2015). Genetic dys-regulation of astrocytic glutamate transporter EAAT2 and its implications in neurological disorders and manganese toxicity. Neurochem Res. 40(2):380-8. PMID: 25064045.
  16. Chen P, Mukhopadhyay S, Bowman A, Karki P, Lee E and Aschner M (2015). Manganese Homeostasis in the Nervous System. J Neurochem. 134(4):601-10. PMID: 25982296.
  17. Karki P, Kim C, Smith K, Son D, Aschner M and Lee E (2015). Transcriptional regulation of the astrocytic excitatory amino acid transporter 1 (EAAT1) via NF-kB and Yin Yang 1 (YY1). J Biol Chem. 290(39):23725-37. PMID: 26269591.
  18. Karki P, Smith K, Aschner M and Lee E (2015), Mechanism of manganese-induced impairment of astrocytic glutamate transporters. Book Chapter. Issues in Toxicology, Manganese in Health and Disease. Edited by Lucio G Costa and Michael Aschner.
  19. Karki P, Smith K, Johnson Jr. J, Lee E (2014). Astrocyte-derived growth factors and estrogen neuroprotection. Mol and Cell Endocrinol. S0303-7207(14)00014-8. PMID:
  20. Karki P, Webb A, Smith K, Johnson Jr. J, Lee K, Son DS, Aschner M and Lee E (2014). Yin Yang 1 is a Repressor of EAAT2 and it Mediates Manganese-induced Decrease of EAAT2 Expression in Astrocytes. Mol Cell Biol. 34(7):1280-9. PMID: 24469401.
  21. Karki P, Webb A, Zerguine A, Choi J, Son DS and Lee E (2014). Mechanism of Raloxifene-induced Upregulation of Glutamate Transporter GLT-1 in Rat Primary Astrocytes. Glia 62(8):1270-83. PMID: 24782323.
  22. Syeda M Kabir, Lee E, Deok-Soo Son (2014). Chemokine network during adipogenesis in 3T3-L1 cells: Differential response between growth and proinflammatory factor in preadipocytes vs. adipocytes. Adipocyte. 3(2):97-106. PMID: 24719782
  23. Exil V, Ping L, Yu Y, Chakraborty S, Caito SW, Wells KS, Karki P, Lee E, Aschner M (2014). Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures. PLoS One. 9(5): e94753. PMID: 24787138.
  24. Karki P, Smith K, Johnson Jr. J, Aschner M and Lee E (2014). Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity. Neurochem Int. S0197-0186(14)00185-5. PMID: 25128239.