OVERVIEW OF NEURODEGENERATIVE DISEASES
Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) \result from the gradual and progressive loss of brain cells, leading to nervous system dysfunction. Mn neurotoxicity referred to as manganism, shares many pathological features of PD. Here in the Lee lab, we study the molecular mechanisms associated with those neurodegenerative diseases in different neural cell types such as astrocytes, neurons, and microglia.
Symptoms of manganism are very similar to those of Parkinson’s–shaking of the hands, arms, and other appendages, loss of motor control, fixed facial expressions or facial muscle spasms, difficulty swallowing, etc.