The human brain contains not only neurons, but also glial cells such as astrocytes and microglia. Neurons are the main cell types to generate signals in the brain, but glial cells must coordinate with neurons for the proper neuronal signals and functions, known as tripartite synapses. One of the major focuses of our lab is to use in vitro cell cultures and in vivo animal models of Mn-induced neurotoxicity, focusing on dopaminergic neurons, astrocytes, and microglia. Since Mn induces similar toxicities to PD, our studies also help us understand PD pathogenesis.
One of the major pathological signs of manganism and PD is progressive dopaminergic neuronal loss and neuronal dysfunction. We are particularly interested in understanding how Mn-induced dysregulation of astrocytic glutamate transporters affects dopaminergic neurodegeneration, as these transporters directly regulate excitotoxicity of dopaminergic neurons at the tripartite synapse. Our work aims to understand the underlying mechanisms of Mn-induced neurotoxicity better, leading to the identification of molecular targets to develop therapies for neurodegenerative diseases.
