Research Publications

Research Publications 2020-2021
  1.  Messeha SS, Zarmouh NO, Soliman KFA. Polyphenols Modulating Effects of PD-L1/PD-1 Checkpoint and EMT-Mediated PD-L1 Overexpression in Breast Cancer. Nutrients. 2021 May 19;13(5):1718. doi: 10.3390/nu13051718. PMID: 34069461;PMCID: PMC8159140.
  2.  Mack N, Mazzio E, Badisa R, Soliman KFA. Metabolic Response to the Mitochondrial Toxin 1-Methyl-4-phenylpyridinium (MPP+) in LDH-A/B Double- knockout LS174T Colon Cancer Cells. Cancer Genomics Proteomics. 2021 May- Jun;18(3 Suppl):385-405. doi: 10.21873/cgp.20267. PMID: 33994363.
  3.  Adinew GM, Taka E, Mendonca P, Messeha SS, Soliman KFA. The Anticancer Effects of Flavonoids through miRNAs Modulations in Triple-Negative Breast Cancer. Nutrients. 2021 Apr 7;13(4):1212. doi: 10.3390/nu13041212. PMID: 33916931; PMCID: PMC8067583.
  4. Luque JS, Vargas M, Wallace K, Matthew OO, Tawk R, Ali AA, Kiros GE, Harris CM, Gwede CK. Engaging the Community on Colorectal Cancer Screening Education: Focus Group Discussions Among African Americans. J Cancer Educ. 2021 Apr 26:1–12. doi: 10.1007/s13187-021-02019-w. Epub ahead of print. PMID: 33904120; PMCID: PMC8075366.
  5. St Louis J, Okere AN. Clinical impact of pharmacist-led antibiotic stewardship programs in outpatient settings in the United States: A scoping review. Am J Health Syst Pharm. 2021 Apr 23:zxab178. doi: 10.1093/ajhp/zxab178. Epub ahead of print. PMID: 33889930; PMCID: PMC8083201.
  6. Hedges JR, Soliman KFA, Southerland WM, D'Amour G, Fernández-Repollet E, Khan SA, Kumar D, Shikuma CM, Rivers BM, Yates CC, Yanagihara R, Thompson WE, Bond VC, Harris-Hooker S, McClure SA, Ofili EO. Strengthening and Sustaining Inter- Institutional Research Collaborations and Partnerships. Int J Environ Res Public Health. 2021 Mar 8;18(5):2727. doi: 10.3390/ijerph18052727. PMID: 33800316; PMCID: PMC7967451.
  7. Agharahimi M, Badisa RB, Mazzio E, Soliman KF, Goodman CB. Cocaine potentiates an inflammatory response in C6 astroglia-like cells. Biomed Rep. 2021 May;14(5):45. doi: 10.3892/br.2021.1421. Epub 2021 Mar 16. PMID: 33786174; PMCID: PMC7995314.
  8. Gallegos KM, Patel JR, Llopis SD, Walker RR, Davidson AM, Zhang W, Zhang K, Tilghman SL. Quantitative Proteomic Profiling Identifies a Potential Novel Chaperone Marker in Resistant Breast Cancer. Front Oncol. 2021 Feb 25;11:540134. doi: 10.3389/fonc.2021.540134. PMID: 33718123; PMCID: PMC7951058.
  9. Mendonca P, Alghamdi S, Messeha S, Soliman KFA. Pentagalloyl glucose inhibits TNF-α-activated CXCL1/GRO-α expression and induces apoptosis-related genes in triple-negative breast cancer cells. Sci Rep. 2021 Mar 11;11(1):5649. doi: 10.1038/s41598-021-85090-z. PMID: 33707603; PMCID: PMC7952910.
  10. Ofori E, Onyameh EK, Gonela UM, Voshavar C, Bricker B, Swanson TL, Eshleman AJ, Schmachtenberg JL, Bloom SH, Janowsky AJ, Ablordeppey SY. New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263. Eur J Med Chem. 2021 Mar 15;214:113243. doi: 10.1016/j.ejmech.2021.113243. Epub 2021 Feb 3. PMID: 33582388; PMCID: PMC7984856.
  11. Asong GM, Amissah F, Voshavar C, Nkembo AT, Ntantie E, Lamango NS, Ablordeppey SY. A Mechanistic Investigation on the Anticancer Properties of SYA013, a Homopiperazine Analogue of Haloperidol with Activity against Triple Negative Breast Cancer Cells. ACS Omega. 2020 Dec 16;5(51):32907-32918. doi: 10.1021/acsomega.0c03495. PMID: 33403252; PMCID: PMC7774091.
  12. Walker RR, Gallegos KM, Bratton MR, Lemieux KP, Zhang K, Wang G, Davidson AM, Tilghman SL. Acquisition of Letrozole Resistance Through Activation of the p38/MAPK Signaling Cascade. Anticancer Res. 2021 Feb;41(2):583-599. doi: 10.21873/anticanres.14810. PMID: 33517263.
  13. Gangapuram M, Eyunni S, Zhang W, Redda KK. Design and Synthesis of Tetrahydroisoquinoline Derivatives as AntiAngiogenesis and Anti-Cancer Agents. Anticancer Agents Med Chem. 2021 Jan 12. doi: 10.2174/1871520621666210112122913. Epub ahead of print. PMID: 33438560.
  14. Gebeyehu A, Surapaneni SK, Huang J, Mondal A, Wang VZ, Haruna NF, Bagde A, Arthur P, Kutlehria S, Patel N, Rishi AK, Singh M. Polysaccharide hydrogel based 3D printed tumor models for chemotherapeutic drug screening. Sci Rep. 2021 Jan 11;11(1):372. doi: 10.1038/s41598-020-79325-8. PMID: 33431915; PMCID: PMC7801509.
  15. Onyameh EK, Bricker BA, Eyunni SVK, Voshavar C, Gonela UM, Ofori E, Jenkins A, Ablordeppey SY. A study of the structure-affinity relationship in SYA16263; is a D<sub>2</sub> receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? Bioorg Med Chem. 2021 Jan 15;30:115943. doi: 10.1016/j.bmc.2020.115943. Epub 2020 Dec 14. PMID: 33338898.
  16. Miranda MA, Marcato PD, Mondal A, Chowdhury N, Gebeyehu A, Surapaneni SK, Bentley MVLB, Amaral R, Pan CX, Singh M. Cytotoxic and chemosensitizing effects of glycoalkaloidic extract on 2D and 3D models using RT4 and patient derived xenografts bladder cancer cells. Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111460. doi: 10.1016/j.msec.2020.111460. Epub 2020 Aug 27. PMID: 33321591.
  17. Kaundal RK, Kalvala AK, Kumar A. Neurological Implications of COVID-19: Role of Redox Imbalance and Mitochondrial Dysfunction. Mol Neurobiol. 2021 Jun 10:1–13. doi: 10.1007/s12035-021-02412-y. Epub ahead of print. PMID: 34110602; PMCID: PMC8190166.
  18. Carrion AJ, Miles JD, Thompson MD, Journee B, Nelson E. Program Evaluation Through the Use of Logic Models. Curr Pharm Teach Learn. 2021 Jul;13(7):789-795.doi: 10.1016/j.cptl.2021.03.006. Epub 2021 Apr 2. PMID: 34074509.
  19. Messeha SS, Zarmouh NO, Asiri A, Soliman KFA. Gene Expression Alterations Associated with Oleuropein-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells. Nutrients. 2020 Dec 7;12(12):3755. doi: 10.3390/nu12123755. PMID: 33297339; PMCID: PMC7762327.
  20. Hilliard A, Mendonca P, Russell TD, Soliman KFA. The Protective Effects of Flavonoids in Cataract Formation through the Activation of Nrf2 and the Inhibition of MMP-9. Nutrients. 2020 Nov 27;12(12):3651. doi:10.3390/nu12123651. PMID: 33261005; PMCID: PMC7759919.
  21. Kommineni N, Nottingham E, Bagde A, Patel N, Rishi AK, Dev SRS, Singh M. Role of nano-lipid formulation of CARP-1 mimetic, CFM-4.17 to improve systemic exposure and response in osimertinib resistant non-small cell lung cancer. Eur J Pharm Biopharm. 2021 Jan;158:172-184. doi: 10.1016/j.ejpb.2020.11.007. Epub 2020 Nov 18. PMID: 33220423; PMCID: PMC7857068.
  22. Diaby V, Almutairi RD, Babcock A, Moussa RK, Ali A. Cost-effectiveness of treatments for HER2-positive metastatic breast cancer and associated metastases: an overview of systematic reviews. Expert Rev Pharmacoecon Outcomes Res. 2021 Jun;21(3):353-364. doi: 10.1080/14737167.2021.1848553. Epub 2020 Dec 1. PMID: 33213205.
  23.  Lamango NS, Nkembo AT, Ntantie E, Tawfeeq N. Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling. Curr Med Chem. 2021;28(18):3476-3489. doi:10.2174/0929867327666201111140825. PMID: 33176634.
  24.  Okere AN, Sanogo V, Alqhtani H, Diaby V. Identification of risk factors of 30-day readmission and 180-day in-hospital mortality, and its corresponding relative importance in patients with Ischemic heart disease: a machine learning approach. Expert Rev Pharmacoecon Outcomes Res. 2020 Nov 11:1-6. doi: 10.1080/14737167.2021.1842200. Epub ahead of print. PMID: 33131344.
  25.  Musa MA, Badisa VLD, Aghimien MO, Eyunni SVK, Latinwo LM. Identification of 7,8-dihydroxy-3-phenylcoumarin as a reversible monoamine oxidase enzyme inhibitor. J Biochem Mol Toxicol. 2021 Feb;35(2):e22651. doi: 10.1002/jbt.22651. Epub 2020 Oct 21. PMID: 33085988.
  26.  Smith T, Affram K, Nottingham EL, Han B, Amissah F, Krishnan S, Trevino J, Agyare E. Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer. Sci Rep. 2020 Oct 12;10(1):16989. doi: 10.1038/s41598-020-73218-6. PMID: 33046724; PMCID: PMC7552424.
  27.  Inkoom A, Ndemazie N, Affram K, Smith T, Zhu X, Underwood P, Krishnan S, Ofori E, Han B, Trevino J, Agyare E. Enhancing efficacy of gemcitabine in pancreatic patient-derived xenograft mouse models. Int J Pharm X. 2020 Sep 23;2:100056. doi: 10.1016/j.ijpx.2020.100056. PMID: 33015617; PMCID: PMC7522377.
  28.  Eraikhuemen N, Lazaridis D, Dutton MT. Emerging Pharmacotherapy to Reduce Elevated Lipoprotein(a) Plasma Levels. Am J Cardiovasc Drugs. 2021 May;21(3):255-265. doi: 10.1007/s40256-020-00437-7. PMID: 32929693.
  29. Son DS, Lee ES, Adunyah SE. The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Netw. 2020 Aug 4;20(4):e29. doi: 10.4110/in.2020.20.e29. PMID: 32895616; PMCID: PMC7458798.
  30. Bagde A, Patel N, Patel K, Nottingham E, Singh M. Sustained release dosage form of noscapine HCl using hot melt extrusion (HME) technique: formulation and pharmacokinetics. Drug Deliv Transl Res. 2021 Jun;11(3):1156-1165. doi: 10.1007/s13346-020-00838-w. PMID: 32880879.
  31. Mazzio E, Badisa R, Mack N, Cassim S, Zdralevic M, Pouyssegur J, Soliman KFA. Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. Cancer Genomics Proteomics. 2020 Sep-Oct;17(5):469-497. doi: 10.21873/cgp.20205. PMID: 32859627; PMCID: PMC7472444.
  32.  Nkemdirim Okere A, Sanogo V, Balkrishnan R, Diaby V. A quantitative analysis of the effect of continuity of care on 30-day readmission and in-hospital mortality among patients with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2020 Sep;29(9):105053. doi: 10.1016/j.jstrokecerebrovasdis.2020.105053. Epub2020 Jun 25. PMID: 32807459.
  33. Hilliard AL, Winchester DE, Russell TD, Hilliard RD. Myocardial infarction classification and its implications on measures of cardiovascular outcomes, quality, and racial/ethnic disparities. Clin Cardiol. 2020 Oct;43(10):1076-1083. doi: 10.1002/clc.23431. Epub 2020 Aug 11. PMID: 32779762; PMCID: PMC7533960.
  34. Messeha SS, Zarmouh NO, Asiri A, Soliman KFA. Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. Eur J Pharmacol. 2020 Oct 15;885:173419. doi: 10.1016/j.ejphar.2020.173419. Epub 2020 Aug 1. PMID: 32750370; PMCID: PMC7541730.
  35. Chowdhury N, Singh M. Current Development of Oral Taxane Formulations: A Review. Crit Rev Ther Drug Carrier Syst. 2020;37(3):205-227. doi: 10.1615/CritRevTherDrugCarrierSyst.2020029699. PMID: 32749138.
  36.  Como M, Carter CW, Larose-Pierre M, O'Dare K, Hall CR, Mobley J, Robertson G, Leonard J, Tew L. Pharmacist-Led Chronic Care Management for Medically Underserved Rural Populations in Florida During the COVID-19 Pandemic. Prev Chronic Dis. 2020 Jul 30;17:E74. doi: 10.5888/pcd17.200265. PMID: 32730199; PMCID: PMC7417018.
  37.  Mendonca P, Soliman KFA. Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity. Antioxidants (Basel). 2020 Jul 24;9(8):659. doi: 10.3390/antiox9080659. PMID: 32722164; PMCID: PMC7463602.
  38. Roy S, Dickey S, Wang HL, Washington A, Polo R, Gwede CK, Luque JS. Systematic Review of Interventions to Increase Stool Blood Colorectal CancerScreening in African Americans. J Community Health. 2021 Feb;46(1):232-244. doi:10.1007/s10900-020-00867-z. PMID: 32583358; PMCID: PMC7313439.
  39.  Arthur P, Patel N, Surapaneni SK, Mondal A, Gebeyehu A, Bagde A, KutlehriaS, Nottingham E, Singh M. Targeting lung cancer stem cells using combination ofTel and Docetaxel liposomes in 3D cultures and tumor xenografts. Toxicol ApplPharmacol. 2020 Aug 15;401:115112. doi: 10.1016/j.taap.2020.115112. Epub 2020Jun 12. PMID: 32540278; PMCID: PMC7437978.
  40. Odedina FT, Behar-Horenstein LS, Fathi P, Kaninjing E, Nguyen J, Askins N, Reams RR, Mochona B, Ezeani A, Lyon D, Jacobs K, Maduka M. Improving Representation of Underrepresented Minority (URM) Students in Oncology Biomedical Research Workforce: Outcome Evaluation from the ReTOOL Program. J Cancer Educ. 2020 Jun 13. doi: 10.1007/s13187-020-01779-1. Epub ahead of print. PMID: 32533539.
  41. Hilliard A, Mendonca P, Soliman KFA. Involvement of NFƙB and MAPK signalingpathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS. J Neuroimmunol. 2020 Aug 15;345:577269. doi: 10.1016/j.jneuroim.2020.577269. Epub 2020 May 26. PMID: 32480240; PMCID: PMC7382303.
  42.  Mochona B, Lyon D, Offringa IA, Redda KK, Reams RR, Odedina F, Wilkie DJ, Stern MC, Carpten JD. Developing a Novel Framework for an Undergraduate Cancer Research Education and Engagement Program for Underrepresented Minority Students: the Florida-California CaRE<sup>2</sup> Research Education Core (REC) Training Program. J Cancer Educ. 2020 May 19:10.1007/s13187-020-01762-w. doi: 10.1007/s13187-020-01762-w. Epub ahead of print. PMID: 32430639; PMCID: PMC7674268.
  43.  Zarmouh NO, Messeha SS, Mateeva N, Gangapuram M, Flowers K, Eyunni SVK, Zhang W, Redda KK, Soliman KFA. The Antiproliferative Effects of Flavonoid MAO Inhibitors on Prostate Cancer Cells. Molecules. 2020 May 11;25(9):2257. doi: 10.3390/molecules25092257. PMID: 32403270; PMCID: PMC7249060.
  44. Becker A, Suther S, Harris C, Pawlowicz G, Tucker G, Dutton M, Close F, Hilliard A, Gragg R. Community-Based Participatory Research at Jacksonville Florida Superfund Ash Site: Toxicology Training to Improve the Knowledge of the Lay Community. Fla Public Health Rev. 2019 May;15(1-7):61-74. PMID: 32337512; PMCID: PMC7181972