Edward Agyare, Ph.D.Division Director and Associate Professor Pharmaceutical Sciences
Edward Agyare, Ph.D., serves as the associate professor, Basic Pharmaceutical Sciences, and as the division director of Pharmaceutical Sciences.
Dr. Agyare’s laboratory works with a variety of nanoparticles for imaging and chemotherapy. He has previously loaded Magnevist®, a contrast agent, into liposomal nanoparticle for magnetic resonance imaging (MRI) of pancreatic cancer in vivo and performed the first comprehensive biodistribution and pharmacokinetic analysis of such a nanoprobe. He has also developed techniques to enhance the signal-to-noise ratio of tumor-imaging using such nanoprobes. Dr. Agyare’s previous work with drug delivery system has focused extensively on using gemcitabine loaded-thermosensitive liposomal nanoparticle-mediated hyperthermia to sensitize tumors to gemcitabine and defined a novel dual mechanism of action involving anti-hypoxic and vascular disrupting properties of this approach. In anticipation of clinical translation of this paradigm, his laboratory develops a theranostic nanoparticle that combines contrast agent and modified existing anticancer agent as one unit that would have the ability for early detection and tumor growth suppression.
- Postdoctoral Fellow: The University of Texas, MD Anderson Cancer Center, Houston, Texas.
- Visiting Fellow: Mayor Clinic Graduate School, Rochester, MN.
- Visiting Scientist: The University of Texas, MD Anderson Cancer Center, Houston, Texas
Areas of Expertise
- Drug Delivery
- Tumor Targeting
- Nanotechnology and Nanomedicine
Mechanisms of nanotechnology-based modified anticancer drug delivery, with emphasis on understanding how various biological barriers influence the effectiveness of delivery systems.
Development of theranostics for the early diagnosis and treatment of pancreatic and colorectal cancers.
Smith, T. Affram, K. Bulumko, E. Agyare, E. (2018) Evaluation of in-vitro cytotoxic effect of 5-FU loaded-chitosan nanoparticles against spheroid models. J Nat Sci., 4(10). PMCID: PMC 6364702
Scarton L, Yoon S, Oh S, Agyare E, Trevino J, Han B, Lee E, Setiawan VW, Permuth JB, Schmittgen TD, Odedina FG, Wilkie DJ (2018). Pancreatic Cancer Related Health Disparities: A Commentary. Cancers (Basel) 10(235) PMCID: PMC 6070801
Kevin Affram, Udofot Ofonime, Renee Reams, Sunil. Krishnan, Mandip. Sachdeva, Jens Rosenberg, Edward Agyare (2017). Smart thermosensitive liposomes for effective solid tumor therapy and in vivo imaging. PLoS ONE: 12(9):e0185116. PMCID: PMC5608370
Udofot, O., Affram K., T. Smith, B. Tshabe, S. Krishnan, M. Sachdeva, E. Agyare (2016). Pharmacokinetics, biodistribution, and therapeutic efficacy of 5-fluorouracil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse. Journal of Nature and Science (JNSCI), 2(1):e171: PMCID: PMC4869888
Kevin Affram, Ofonime Udofot, Edward K. Agyare. Cytotoxicity of gemcitabine-loaded thermosensitive liposomes in pancreatic cancer cell lines. Integr Cancer Sci Therapy, 2015. 2(2): 133-142 PMID: 26090123, PMCID:PMC4469203