BASIC SCIENCES DIVISION (2014-2017)

  1. Mazzio EA, Bauer D, Mendonca P, Taka E, Soliman KF. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells. J Neuroimmunol. 2017 Jan 15; 302:10-19. doi: 10.1016/j.jneuroim.2016.11.012. PubMed PMID: 27956075; PubMed Central PMCID: PMC5201440.
  2. Mazzio EA, Soliman KF. HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics. 2017 01-02; 14(1):17-33. PubMed PMID: 28031235 PubMed Central PMCID: PMC5267498.
  3. Cobourne-Duval MK, Taka E, Mendonca P, Bauer D, Soliman KF.  The Antioxidant Effects of Thymoquinone in Activated BV-2 Murine Microglial Cells. Neurochem Res. 2016 Dec 41(12):3227-3238. PubMed PMID: 27585756 PubMed Central PMCID: PMC5116410.
  4. Mochona B, Jackson T, McCauley D, Mazzio E, Redda KK.  Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs. J Heterocycl Chem. 2016 Nov 53(6):1871-1877. PubMed PMID: 27956751 PubMed Central PMCID: PMC5147751.
  5. Nkembo AT, Ntantie E, Salako OO, Amissah F, Poku RA, Latinwo LM, Lamango NS. The antiangiogenic effects of polyisoprenylated cysteinyl amide inhibitors in HUVEC, chick embryo and zebrafish is dependent on the polyisoprenyl moiety. Oncotarget. 2016 Oct 187(42):6819468205. doi: 10.18632/oncotarget.11908. PubMed PMID: 27626690.
  6. Gangapuram M, Jean R, Mazzio E, Badisa R, Eyunni S, Goodman CB, Redda KK, Soliman KF. Substituted Tetrahydroisoquinolines as Microtubule-destabilizing Agents in Triple Negative Human Breast Cancer Cells. Anticancer Res. 2016 Oct 36(10):5043-5052. PubMed PMID: 27798863 PubMed Central PMCID: PMC5104193.
  7. Boulin M, Diaby V, Tannenbaum C. Preventing Unnecessary Costs of Drug-Induced Hypoglycemia in Older Adults with Type 2 Diabetes in the United States and Canada. PLoS One. 2016 Sep 20 11(9):e0162951. doi: 10.1371/journal.pone.0162951. PubMed PMID: 27648831 PubMed Central PMCID: PMC5029920.
  8. Ramsubhag RR, Massaro CL, Dadich CM, Janeczek AJ, Hoang TT, Mazzio EA, Eyunni S, Soliman KF, Dudley GB. Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances. Org Biomol Chem. 2016 Aug 16; 14(33):7855-8. doi: 10.1039/c6ob01351a. PubMed PMID: 27492587; PubMed Central PMCID: PMC5008855.
  9. Ofori E, Zhu XY, Etukala JR, Peprah K, Jordan KR, Adkins AA, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands. Bioorg Med Chem. 2016 Aug 15 24(16):3464-71. doi: 10.1016/j.bmc.2016.05.053. PubMed PMID: 27312422 PubMed Central PMCID: PMC5060005.
  10. Etukala JR, Zhu XY, Eyunni SV, Onyameh EK, Ofori E, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores. Bioorg Med Chem. 2016 Aug 15 24(16):3671-9. doi: 10.1016/j.bmc.2016.06.011. PubMed PMID: 27364609 PubMed Central PMCID: PMC5209244.
  11. Xiao H, Tan F, Goovaerts P, Adunlin G, Ali AA, Gwede CK, Huang Y. Impact of Comorbidities on Prostate Cancer Stage at Diagnosis in Florida. Am J Mens Health. 2016 Jul; 10(4):285-95. doi: 10.1177/ 1557988314564593. Epub 2014 Dec 26. PubMed PMID: 25542838; PubMed Central PMCID: PMC4483149.
  12. Mochona B, Qi X, Euynni S, Sikazwi D, Mateeva N, Soliman KF. Design and evaluation of novel oxadiazole derivatives as potential prostate cancer agents. Bioorg Med Chem Lett. 2016 Jun 15; 26(12):2847-51. doi: 10.1016/j.bmcl.2016.04.058. Epub 2016 Apr 21. PubMed PMID: 27156770; PubMed Central PMCID: PMC4888807.
  13. Diaby V, Ali AA, Adunlin G, Kohn CG, Montero AJ. Parameterization of a disease progression simulation model for sequentially treated metastatic human epidermal growth factor receptor 2 positive breast cancer patients. Curr Med Res Opin. 2016 Jun; 32(6):991-6. doi: 10.1185/03007995.2016.1149056. Epub 2016 Mar 2. PubMed PMID: 26824145; PubMed Central PMCID: PMC4959115.
  14. Zarmouh NO, Messeha SS, Elshami FM, Soliman KF. Natural Products Screening for the Identification of Selective Monoamine Oxidase-B Inhibitors. European J Med Plants. 2016 May15(1). pii: 14802. PubMed PMID: 27341283 PubMed Central PMCID: PMC4898948.
  15. Doddapaneni R, Patel K, Owaid IH, Singh M. Tumor neovasculature-targeted cationic PEGylated liposomes of gambogic acid for the treatment of triple-negative breast cancer. Drug Deliv. 2016 May; 23(4):1232-41. doi: 10.3109/10717544.2015.1124472. Epub 2015 Dec 24. PubMed PMID: 26701717; PubMed Central PMCID: PMC5024788.
  16. Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Mol Cell Biol. 2016 Apr 15; 36(9):1383-94. doi: 10.1128/MCB.00912-15. Print 2016 May. PubMed PMID: 26929200; PubMed Central PMCID: PMC4836213.
  17. Williams HN, Lymperopoulou DS, Athar R, Chauhan A, Dickerson TL, Chen H, Laws E, Berhane TK, Flowers AR, Bradley N, Young S, Blackwood D, Murray J, Mustapha O, Blackwell C, Tung Y, Noble RT. Halobacteriovorax, an underestimated predator on bacteria: potential impact relative to viruses on bacterial mortality. ISME J. 2016 Feb 10(2):491-9. doi: 10.1038/ismej.2015.129. PubMed PMID: 26251870 PubMed Central PMCID: PMC4737939.
  18. Udofot O, Affram K, Smith T, Tshabe B, Krishnan S, Sachdeva M, Agyare E. Pharmacokinetic, biodistribution and therapeutic efficacy of 5-fluorouAdvisory Committeeil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse. J Nat Sci. 2016 2(1). pii: e171. PubMed PMID: 27200415 PubMed Central PMCID: PMC4869888.
  19. Messeha SS, Zarmouh NO, Taka E, Gendy SG, Shokry GR, Kolta MG, Soliman KF. The Role of Monocarboxylate Transporters and Their Chaperone CD147 in Lactate Efflux Inhibition and the Anticancer Effects of Terminalia chebula in Neuroblastoma Cell Line N2-A. European J Med Plants. 2016 12(4). pii: EJMP.23992. PubMed PMID: 27158628 PubMed Central PMCID: PMC4857771.
  20. Mazu TIK, Bricker BA, Flores-Rozas H, Ablordeppey SY.  The Mechanistic Targets of Antifungal Agents: An Overview.  Mini reviews in medicinal chemistry.  2016:16(7):555-78. PubMed PMID: 26776224 PubMed Central PMCID: PMC5215921.
  21. Godugu C, Doddapaneni R, Patel AR, Singh R, Mercer R, Singh M.  Novel Gefitinib Formulation with Improved Oral Bioavailability in Treatment of A431 Skin Carcinoma. Pharm Res. 2016 Jan 33(1):13754. doi: 10.1007/s11095-015-1771-6. PubMed PMID: 26286185 PubMed Central PMCID: PMC4774891.
  22. Williams HN, Lymperopoulou DS, Athar R, Chauhan A, Dickerson TL, Chen H, Laws E, Berhane TK, Flowers AR, Bradley N, Young S, Blackwood D, Murray J, Mustapha O, Blackwell C, Tung Y, Noble RT. Halobacteriovorax, an underestimated predator on bacteria: potential impact relative to viruses on bacterial mortality. ISME J. 2016 Feb; 10(2):491-9. doi: 10.1038/ismej.2015.129. Epub 2015 Aug 7. PubMed PMID: 26251870; PubMed Central PMCID: PMC4737939.
  23. Udofot O, Affram K, Smith T, Tshabe B, Krishnan S, Sachdeva M, Agyare E. Pharmacokinetic, biodistribution and therapeutic efficacy of 5-fluorouracil-loaded pH-sensitive PEGylated liposomal nanoparticles in HCT-116 tumor bearing mouse. J Nat Sci. 2016; 2(1). Pii: e171. PubMed PMID: 27200415; PubMed Central PMCID: PMC4869888.
  24. Katam R, Chibanguza K, Latinwo LM, Smith D. Proteome Biomarkers in Xylem Reveal Pierce’s Disease Tolerance in Grape. J Proteomics Bioinform. 2015 8(9):217-224. PubMed PMID: 27019567 PubMed Central PMCID: PMC4807612.
  25. Flores-Rozas H, Jaafar L, Xia L. The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells. Adv Biosci Biotechnol. 2015 6(6):408-418. PubMed PMID: 26900494 PubMed Central PMCID: PMC4758339.
  26. Tawk R, Dutton M. Racial Differences in Length of Stay for Patients Who Leave Against Medical Advice from U.S. General Hospitals. Int J Environ Res Public Health. 2015 Dec 31; 13(1). pii: E95. doi: 10.3390/ijerph13010095. PubMed PMID: 26729149; PubMed Central PMCID: PMC4730486.
  27. Williams MD, Nguyen T, Carriere PP, Tilghman SL, Williams C. Protein Kinase CK2 Expression Predicts Relapse Survival in ERα Dependent Breast Cancer, and Modulates ERα Expression in Vitro. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010036. doi: 10.3390/ijerph13010036. PubMed PMID: 26703694; PubMed Central PMCID: PMC4730427.
  28. Tawk R, Abner A, Ashford A, Brown CP. Differences in Colorectal Cancer Outcomes by Race and Insurance. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010048. doi: 10.3390/ ijerph13010048. PubMed PMID: 26703651; PubMed Central PMCID: PMC4730439.
  29. Carriere PP, Llopis SD, Naiki AC, Nguyen G, Phan T, Nguyen MM, Preyan LC, Yearby L, Pratt J, Burks H, Davenport IR, Nguyen TA, Parker-Lemieux K, Payton-Stewart F, Williams CC, Boué SM, Burow ME, Collins-Burow B, Hilliard A, Davidson AM, Tilghman SL. Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010010. doi: 10.3390/ijerph13010010. PubMed PMID: 26703648; PubMed Central PMCID: PMC4730401.
  30. Patel K, Chowdhury N, Doddapaneni R, Boakye CH, Godugu C, Singh M. Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer. J Pharm Sci. 2015 Dec; 104(12):4417-26. Doi: 10.1002/jps.24637. Epub 2015 Sep 15. PubMed PMID: 26372815; PubMed Central PMCID: PMC4706797.
  31. Adunlin G, Diaby V, Montero AJ, Xiao H. Multicriteria decision analysis in oncology. Health Expect. 2015 Dec; 18(6):1812-26. Doi: 10.1111/hex.12178. Epub 2014 Mar 17. Review. PubMed PMID: 24635949; PubMed Central PMCID: PMC4318795.
  32. Adunlin G, Diaby V, Xiao H. Application of multicriteria decision analysis in health care: a systematic review and bibliometric analysis. Health Expect. 2015 Dec; 18(6):1894-905. doi: 1111/hex.12287. Epub 2014 Oct 18. Review. PubMed PMID: 25327341; PubMed Central PMCID: PMC4402125.
  33. Affram K, Udofot O, Cat A, Agyare E. In vitro and in vivo antitumor activity of gemcitabine loaded thermosensitive liposomal nanoparticles and mild hyperthermia in pancreatic cancer. Int J Adv Res (Indore). 2015 Oct; 3(10):859-874. PubMed PMID: 26677454; PubMed Central PMCID: PMC4677791.
  34. Mazzio E, Georges B, McTier O, Soliman KF. Neurotrophic Effects of Mu Bie Zi (Momordica cochinchinensis) Seed Elucidated by High-Throughput Screening of Natural Products for NGF Mimetic Effects in PC-12 Cells. Neurochem Res. 2015 Oct; 40(10):2102-12. doi: 10.1007/s11064-015-1560-y. Epub 2015 Apr 11. PubMed PMID: 25862192; PubMed Central PMCID: PMC4600633.
  35. Taka E, Mazzio EA, Goodman CB, Redmon N, Flores-Rozas H, Reams R, Darling-Reed S, Soliman KF. Anti-inflammatory effects of thymoquinone in activated BV-2 microglial cells. J Neuroimmunol. 2015 Sep 15; 286:5-12. doi: 10.1016/j.jneuroim.2015.06.011. Epub 2015 Jun 27. PubMed PMID: 26298318; PubMed Central PMCID: PMC4548297.
  36. Bauer D, Redmon N, Mazzio E, Taka E, Reuben JS, Day A, Sadrud-Din S, Flores-Rozas H, Soliman KF, Darling-Reed S. Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling. Cytokine. 2015 Sep; 75(1):117-26. doi: 10.1016/j.cyto.2014.12.007. Epub 2015 Jun 20. PubMed PMID: 26100848; PubMed Central PMCID: PMC4532635.
  37. Goovaerts P, Xiao H, Adunlin G, Ali A, Tan F, Gwede CK, Huang Y. GEOGRAPHICALLY-WEIGHTED REGRESSION ANALYSIS OF PERCENTAGE OF LATE-STAGE PROSTATE CANCER DIAGNOSIS IN FLORIDA. Appl Geogr. 2015 Aug 1; 62:191-200. PubMed PMID: 26257450; PubMed Central PMCID:
  38. Boakye CH, Patel K, Singh M. Doxorubicin liposomes as an investigative model to study the skin permeation of nanocarriers. Int J Pharm. 2015 Jul 15; 489(1-2):106-16. doi: 10.1016/ j.ijpharm .2015.04.059. Epub 2015 Apr 21. PubMed PMID: 25910414; PubMed Central PMCID: PMC4478089.
  39. Odewumi CO, Latinwo LM, Ruden ML, Badisa VL, Fils-Aime S, Badisa RB. Modulation of cytokines and chemokines expression by NAC in cadmium chloride treated human lung cells. Environ Toxicol. 2015 Jul 3. doi: 10.1002/tox.22165. [Epub ahead of print] PubMed PMID: 26138014; PubMed Central PMCID: PMC4698366. [Epub ahead of print]
  40. Mathis AL, Rooks RN, Tawk RH, Kruger DJ. Neighborhood Influences and BMI in Urban Older Adults. J Appl Gerontol. 2015 May 13. Pii: 0733464815584670. [Epub ahead of print] PubMed PMID: 25972394; PubMed Central PMCID: PMC4644114. [Epub ahead of print]
  41. Li N, Chen H, Williams HN. Genome-wide comparative analysis of ABC systems in the Bdellovibrio-and-like organisms. Gene. 2015 May 10; 562(1):132-7. doi: 10.1016/j.gene.2015.02.062. Epub 2015 Feb 21. PubMed PMID: 25707746; PubMed Central PMCID: PMC4492526.
  42. Diaby V, Tawk R, Sanogo V, Xiao H, Montero AJ. A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer. Breast Cancer Res Treat. 2015 May; 151(1):27-40. doi: 10.1007/s10549015-3383-6. Epub 2015 Apr 19. Review. PubMed PMID: 25893588; PubMed Central PMCID: PMC4530780.
  43. Odewumi CO, Fils-Aime S, Badisa VL, Latinwo LM, Ruden ML, Ikediobi C, Badisa RB. Chemoprotective effect of monoisoamyl 2, 3-dimercaptosuccinate (MiADMS) on cytokines expression in cadmium chloride treated human lung cells. Environ Toxicol. 2015 May-Jun; 30(6):704-11. doi: 10.1002/tox.21948. Epub 2014 Jan 13. PubMed PMID: 24420767; PubMed Central PMCID: PMC4096614.
  44. Mochona B, Mazzio E, Gangapurum M, Mateeva N, Redda KK. Synthesis of Some Benzimidazole Derivatives Bearing 1, 3,4Oxadiazole Moiety as Anticancer Agents. Chem Sci Trans. 2015 Apr; 4(2):534-540. PubMed PMID: 26451350; PubMed Central PMCID: PMC4594831.
  45. Mateeva N, Gangapuram M, Mazzio E, Eyunni S, Soliman KF, Redda KK. Biological evaluation of synthetic chalcone and flavone derivatives as anti-inflammatory agents. Med Chem Res. 2015 Apr; 24(4):1672-1680. PubMed PMID: 25866456; PubMed Central PMCID: PMC4390068.
  46. Elhag R, Mazzio EA, Soliman KF. The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines. Anticancer Res. 2015 Mar; 35(3):1263-9. PubMed PMID: 25750273; PubMed Central PMCID PMC4355951.
  47. Flores-Rozas H, Jaafar L, Xia L. The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells. Adv Biosci Biotechnol. 2015; 6(6):408-418. Epub 2015 Jun 1. PubMed PMID: 26900494; PubMed Central PMCID: PMC4758339.
  48. Katam R, Chibanguza K, Latinwo LM, Smith D. Proteome Biomarkers in Xylem Reveal Pierce’s Disease Tolerance in Grape. J Proteomics Bioinform. 2015; 8(9):217-224. PubMed PMID: 27019567; PubMed Central PMCID: PMC4807612.
  49. Reams RR, Jones-Triche J, Chan OT, Hernandez BY, Soliman KF, Yates C. Immunohistological analysis of ABCD3 expression in Caucasian and African American prostate tumors. Biomed Res Int.; 2015: 132981. doi: 10.1155/2015/132981. Epub 2015 Jan 31. PubMed PMID: 25802834; PubMed Central PMCID: PMC4329846.
  50. Zarmouh NO, Mazzio EA, Elshami FM, Messeha SS, Eyunni SV, Soliman KF. Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B. Evid Based Complement Alternat Med.;2015:852194. doi: 10.1155/2015/852194. Epub 2015 Oct 19. PubMed PMID: 26557867; PubMed Central PMCID: PMC4629031.
  51. Udofot O, Affram K, Israel B, Agyare E. Cytotoxicity of 5-fluorouracilloaded pH-sensitive liposomal nanoparticles in colorectal cancer cell lines. Integr Cancer Sci Ther. 2015; 2(5):245-252. Epub 2015 Oct 9. PubMed PMID: 26691592; PubMed Central PMCID: PMC4681526.
  52. Chen H, Brinkac LM, Mishra P, Li N, Lymperopoulou DS, Dickerson TL, Gordon-Bradley N, Williams HN, Badger JH. Draft genome sequences for the obligate bacterial predators Bacteriovorax spp. of four phylogenetic clusters. Stand Genomic Sci. 2015 Mar 24; 10:11. doi: 10.1186/1944-3277-10-11. eCollection 2015. PubMed PMID: 26203326; PubMed Central PMCID: PMC4511183.
  53. Li N, Williams HN. 454 Pyrosequencing reveals diversity of Bdellovibrio and like organisms in fresh and salt water. Antonie Van Leeuwenhoek. 2015 Jan; 107(1):305-11. doi: 10.1007/s10482-0140327-9. Epub 2014 Nov 9. PubMed PMID: 25380719; PubMed Central PMCID: PMC4492430.
  54. Gordon-Bradley N, Li N, Williams HN. Bacterial community structure in freshwater springs infested with the invasive plant species Hydrilla verticillata. Hydrobiologia. 2015 Jan; 742(1):221-232. PubMed PMID: 26207069; PubMed Central PMCID: PMC4508756.
  55. Affram K, Udofot O, Agyare E. Cytotoxicity of gemcitabine-loaded thermosensitive liposomes in pancreatic cancer cell lines. Integr Cancer Sci Ther. 2015; 2(2):133-142. PubMed PMID: 26090123; PubMed Central PMCID: PMC4469203.
  56. Deiab S, Mazzio E, Eyunni S, McTier O, Mateeva N, Elshami F, Soliman KF. 1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells. Evid Based Complement Alternat Med. 2015; 2015:276946. doi: 10.1155/2015/276946. Epub 2015 Mar 30. PubMed PMID: 25918543; PubMed Central PMCID: PMC4396556.
  57. Glass-Holmes M, Aguilar BJ, Gragg RD 3rd, Darling-Reed S, Goodman CB. Characterization of 2-amino-1-methyl-6phenylimidazo [4,5b] pyridine at androgen receptor: mechanistic support for its role in prostate cancer. Am J Cancer Res. 2014 Dec 15; 5(1):191-200. eCollection 2015. PubMed PMID: 25628930; PubMed Central PMCID: PMC4300711.
  58. Badisa RB, Kumar SS, Mazzio E, Haughbrook RD, Allen JR, Davidson MW, Fitch-Pye CA, Goodman CB. N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglialike cells. PLoS One. 2015 Jan 24; 10(1):e0114285. doi: 10.1371/journal.pone.0114285. eCollection 2015. PubMed PMID
  59. Poku RA, Amissah F, Duverna R, Aguilar BJ, Kiros GE, Lamango NS. Polyisoprenylated methylated protein methyl esterase as a putative drug target for androgen-insensitive prostate cancer. Ecancermedicalscience. 2014 Aug 28 8:459. doi: 10.3332/ecancer.2014.459. PubMed PMID: 25228915 PubMed Central PMCID: PMC4154947.
  60. Desai PR, Cormier AR, Shah PP, Patlolla RR, Paravastu AK, Singh M. (31)P solid-state NMR based monitoring of permeation of cell penetrating peptides into skin. Eur J Pharm Biopharm. 2014 Feb 86(2):190-9. doi: 10.1016/j.ejpb.2013.05.003. PubMed PMID: 23702274 PubMed Central PMCID: PMC3884066.