Cancer Related Faculty Publications

•Reams RR, Kalari KR, Wang H, Odedina FT, Soliman KF, Yates C. Detecting gene-gene interactions in prostate disease in African American men. Infect Agent Cancer. 6 Suppl 2:S1. (2011)

•Hardaway, C, Badisa, R and Soliman KF. Effect of ascorbic acid and hydrogen peroxide on mouse neuroblastoma cells. Molecular Medicine Reports 5:1449-52.(2012)

•Mazzio, E A and Soliman, K F.A. Basic concepts of epigenetics: Impact of environmental signals on gene expression Epigenetics 7, 119 – 130 (2012)

•Mazzio, Elizabeth A, Boukli, N, Rivera, N and Soliman, K. F. A. Pericellular pH homeostasis is a primary function of the Warburg effect; Inversion of metabolic systems to control lactate steady state in tumor cells. Cancer Sciences: 103(3):422-32 2012

•Taka E, Mazzio E, Soliman KFA, and Reams R. R. Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells. NeuroToxicology: 33: 162–168. (2012)

•Mazzio E and Soliman KFA. Whole genome expression profile in neuroblastoma cells exposed to 1- methyl4-phenylpyridine. Neurotoxicology in press 2013

•Stephenson AP, Schneider JA, Nelson BC, Atha DH, Jain A, Soliman KF, Aschner M, Mazzio E, Renee Reams R. Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine. Toxicol Lett. In press 2013

•Godugu, Chandraiah, Apura R. Patel, Utkarsh Desai, Terrick Andey, Alexandria Sams and Mandip Singh. AlgiMatrix™ Based 3D Cell Culture System as an In-Vitro Tumor Model for Anticancer Studies, PLoS ONE. 2013 January 18, 8(1): e53708. doi:10.1371. PMC3548811.

•Stephenson AP, Reams, RR. Manganese-Induced Oxidative DNA Damage in Neuronal SH-SY5Y Cells Attenuation of thymine base lesions by glutathione and N-acetylcysteine. Toxicol Lett. 2013 Apr 26;218(3):299-307. doi: 10.1016/j.toxlet.2012.12.024. Epub 2013 Jan 4.

•Archibong, E., Wang, L., Ivanov, I., Lita, A., Redda, K., Mateeva, N., Investigation of the binding of dioxin selective pentapeptides to a polyaniline matrix . Synthetic Metals, 162, (13–14), 1255-1263, 2012.

•Ayuk-Takem L, Amissah F, Aguilar BJ, Lamango NS. Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration. Environ Toxicol. 2012 Apr 4. doi: 10.1002/tox.21773. [Epub ahead of print]

•Lee SO, Andey T, Jin UH, Kim K, Sachdeva M, Safe S. The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene. 2012 Jul 5;31(27):3265-76. doi: 10.1038/onc.2011.504. Epub 2011 Nov 14.

•Mazzio EA, Boukli N. Rivera N. Soliman KF. Pericellular pH homeostasis is a primary function of the Warburg effect: Inversion of metabolic systems to control lactate steady state in tumor cells. Cancer Sci. 2012 Feb 9. doi: 10.1111/j. 1349-7006.2012.02206. PMC3294166.

•Mazzio EA, Soliman KF, Basic concepts of epigenetics: Impact of environmental signals on gene expression. Epigenetics: Epigenetics. 2012 Feb;7(2):119-30, 2012. PMC3335905.

•Mazzio E and Soliman KFA. Whole genome expression profile in neuroblastoma cells exposed to 1- methyl4-phenylpyridine. Neurotoxicology. 2012 Oct; 33(5):1156-69. doi: 10.1016/j.neuro.2012.06.009. Epub 2012 Jul 7. PMCID: PMC3470775 [Available on 2013/10/1].

•Nkrumah-Elie YM, Reuben JS, Hudson A, Taka E, Badisa R, Ardley T, Israel B, Sadrud-Din SY, Oriaku E, Darling-Reed SF. Diallyl trisulfide as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A cells. Food Chem Toxicol. 2012 Jul;50(7):2524-30. Epub 2012 Apr 16. PMC3374924.

•Nkrumah-Elie YM, Reuben JS, Hudson AM, Taka E, Badisa R, Ardley T, Israel B, Sadrud-Din SY, Oriaku ET, Darling-Reed SF. The attenuation of early benzo (a) pyrene-induced carcinogenic insults by diallyl disulfide (DADS) in MCF-10A cells. Nutr Cancer. 2012; 64(7):1112-21. Doi: 10.1080/01635581.2012.712738. Epub 2012 Sep 24. PMCID: PMC3559020 [Available on 2013/9/24].

•Christina M. Hardaway, Ramesh B. Badisa, and Karam F.A. Soliman (2012) Effect of ascorbic acid and hydrogen peroxide on mouse neuroblastoma cells. International Journal of Molecular Medicine. PMID: 22525868 [PubMed – indexed for MEDLINE] PMC3374924

•Okoro ON, Odedina FT, Reams RR, Smith WT. Clinical cultural competency and knowledge of health disparities among pharmacy students. Am J Pharm Educ. 2012 Apr 10; 76(3):40. PMC3327238.

•Russell LH Jr, Mazzio E, Badisa RB, Zhu ZP, Agharahimi M, Oriaku ET, Goodman CB. Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells. CB Anticancer Res. 2012 May; 32(5):1595-602. PMC3356927.

•Russell LH Jr, Mazzio E, Badisa RB, Zhu ZP, Agharahimi M, Oriaku ET, Goodman CB. Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells. CB Anticancer Res. 2012 May; 32(5):1595-602. PMC3356927.

•Taka E., Mazzio, E., Soliman, K.F.A., Reams, R.R. Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells. NeuroToxicology 33 2012 Mar 162–168. PMC3348586.

•Zhonglian Wan, Musiliyu Musa, Patrick Joseph and John S. Cooperwood. Synthesis and Biological Activity of 3-N-Substituted Estrogen Derivatives as Breast Cancer Agents. Submitted to Medicinal Chemistry (In Press) 2012 July. PMID: 22876946

•David Bauer, Elizabeth Mazzio E, Karam F.A. Soliman, Equar Taka, Tracey Womble, Jayne S. Reuben and Selina Darling-Reed S * Diallyl disulfide inhibits TNFα-induced CCL2 release in MDA-MB-231 cells. Submitted to: Cytokine Research March, 2012.

•Oneil Newell, Jayne S. Reuben, Lashaundra Taylor, Alicia Hudson, Agnes Day, Marti Jett, Sekeenah Sadrud-Din, Ronald Thomas, Ebenezer Oriaku, Selina Darling-Reed. Diallyl Sulfide Inhibits Diethylstilbestrol induced lipid peroxidation by inducing Glutathione S Transferase activity and gene expression in male Sprague Dawley Rats. Submitted to Anticancer Research March 2012.

•Oneil Newell, Jayne S. Reuben, Lashaundra Taylor, Alicia Hudson, Agnes Day, Rasha Hammamieh, Marti Jett, Ronald Thomas, Selina Darling-Reed. Diallyl Sulfide’s alteration of Diethylstillbestrol induced Breast Tumor via the regulation of the JAK/STAT pathway in Female ACI rats. Submitted to Journal of Nutrition and Cancer March 2012.

•Aguilar B, Amissah F, Duverna R, Lamango NS. Polyisoprenylation potentiates the inhibition of polyisoprenylated methylated protein methyl esterase and the cell degenerative effects of sulfonyl fluorides. Curr Cancer Drug Targets. 2011 Jul 1;11(6):752-62. PMC3313490.

•Amissah F, Taylor S, Duverna R, Ayuk-Takem LT, Lamango NS. Regulation of polyisoprenylated methylated protein methyl esterase by polyunsaturated fatty acids and prostaglandins. Eur J Lipid Sci Technol. 2011 Nov; 113(11):1321-1331. PMC3313489.

•Bridgette Israel, Sekeenah Sadrud-Din Ebenezer Oriaku, Selina F. Darling-Reed*. The Inhibition of Benzo[a]pyrene Induced Carcinogenesis by Diallyl Disulfide in MCF-10A cells. Submitted to Journal of Nutrition and Cancer November, 2011.

•Chougule M, Patel AR, Sachdeva P, Jackson T, Singh M. Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer. Lung Cancer. 2011 Mar;71(3):271-82. PMC3094914.

•Chougule MB, Patel A, Sachdeva P, Jackson T, Singh M. Enhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer. PLoS One. 2011;6(11):e27394. PMC3216931.

•Chougule M, Patel AR, Jackson T, Singh M. Antitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer. PLOS One. 2011; 6(3):e17733. PMC3057970.

•Hernan Flores-Rozas. “Differential Contribution of Mismatch Repair Genes in the Processing of DNA Damage” (2011) Infectious Agents and Cancer journal

•Mateeva N, Deiab S, Archibong E, Tasheva D, Mochona B, Gangapuram M, Redda K. Dansyl – Substituted Aza Crown Ethers:
Complexation with Alkali, Alkaline Earth Metal Ions and Ammonium. Int J Chem. 2011 Feb;3(1):10-17. PMC3129597.

•Mazzio E, Boukli N.M, Soliman KFA. pH dependent morphological, proteomic and whole genomic differential changes in neuroblastoma (Submitted 2011 Life Sciences).

•Min Peng, Zheqiong Yang, Hao Zhang, Guanghu Wang, Lahcen Jaafar, Janine L. Bakker, Min Liu, Johan J.P. Gille, Hernan Flores-Rozas, Jianming Xu, Nahid F. Mivechi, Quinten Waisfisz, and Lan Ko*. “GT198 Is a Breast and Ovarian Cancer Susceptibility Gene at

•Musa MA, Badisa, VLD., Latinwo, LM, Cooperwood, JS, Sinclair, A., Abdullah, A. Cytotoxic Activity of New Acetoxycoumarin Derivatives in Cancer Cell Lines. Anticancer Research 2011, 31, 2017-2022. PMC3358800.

•Musa MA, Cooperwood JS, Khan MO, Rahman T. IIn vitro Antiproliferative Activity of Benzopyranone Derivatives in Comparison with Standard Chemotherapeutic Drugs. Archiv Der Pharmazie 2011, Feb;344(2): 102-10. PMC3361755.

•Nkrumah-Elie, Y., Hudson, A., Taka, E., Badisa, R., Bauer, D., Gallimore, S., Israel, B., Ardley, T., Oriaku, E., Thomas, R., Darling-Reed, S.; The Attenuation of Early Benzo[a]pyrene Induced Carcinogenic Insults by Diallyl Disulfide in MCF-10A Cells, Nutrition and Cancer, Nov. 2011 (SUBMITTED).

•Odedina FT, Dagne G, Pressey S, Odedina O, Emanuel F, Scrivens J, Reams RR, Adams A, Larose-Pierre M. Prostate cancer health and cultural beliefs of black men: The Florida Prostate Cancer Disparity Project. Infect Agent Cancer. 2011 Sep 23;6 Suppl 2:S10. Epub 2011 Sep 23. PMCID: PMC3194180. (Doesn’t acknowledge RCMI).

•Patel AR, Chougule MB, Patlolla R, Gwandi W, Ian T, Jackson T, M. Singh. Anticancer activity in combination of docetaxel and celecoxib nanostructured lipid carriers, Molecular Pharmaceutics (Submitted). 2011

•Reams RR, Kalari KR, Wang H, Odedina FT, Soliman KF, Yates C.Detecting gene-gene interactions in prostate disease in African American men. Infectious Agents and Cancer 2011, 6(Suppl 2):S1. PMC3194179.

•Russell LH Jr, Mazzio E, Badisa RB, Zhu ZP, Agharahimi M, Millington DJ, Goodman CB. Differential Cytotoxicity of Triphala and its Phenolic Constituent Gallic acid on Human Prostate Cancer LNCap and Normal Cells. Anticancer Research, 2011 Nov;31(11):3739-45. PMC3328776.

•Goovaerts P and Xiao H. Impact of place and time on proportion of late-stage diagnosis: the case of prostate cancer in Florida, 1981-2007. Spat Spatiotemporal Epidemiol. 2012 Sep;3(3):243-53. Epub 2012 Mar 13. PMC3389349. [PubMed – in process].

•Pedroso F, Raut C, Xiao H. et al. Has the Survival Rate for Surgically Resected Gastric Gastrointestinal Stromal Tumors Improved in the Tyrosine Kinase Inhibitor Era? Annals of Surgical Oncology. 2012 Jan 1;19:1748-1758.

•Xiao H, Tan F and Goovaerts P. Racial and geographic disparities in late-stage prostate cancer diagnosis in Florida. J Health Care Poor Underserved. 2011;22(4 Suppl):187-99.

•Goovaerts P and Xiao H. Geographical, temporal and racial disparities in late-stage prostate cancer incidence across Florida: a multiscale joinpoint regression analysis. International Journal of Health Geographics. 2011;10:63 .

•Hudson, A., Meeks, M., Honeywell, M., Welch, T., Decker, K., Johnson, A., Robinson, T. “PROGENSA PCA3 Assay: A Step Forward in the Detection of Prostate Cancer” Uspharmacist.com Jan 23, 2013.

•Odedina1*, Folakemi T, Dagne2, Getachew, Pressey1, Shannon, Odedina3, Oladapo, Emanuel4, Frank, Scrivens4, John, Reams4, R Renee, Adams5, Angela, LaRose-Pierre4, Margareth. From The Science of Global Prostate Cancer Disparities in Black Men, Jacksonville, FL, USA. 27-29 August 2010. Infectious Agents and Cancer 2011, 6(Suppl 2):S10. http://www.infectagentscancer.com/content/6/S2/S10.

•Folakemi T. Odedina, PhD1; Getachew Dagne, PhD2; Shannon Pressey, MS1; Angela Adams, PharmD3; Oladapo Odedina, CFE;4 John Scrivens, PhD5; Frank Emanuel, PharmD5; Margareth LaRose-Pierre, PharmD5. Factors Responsible for the Disparate Enrollment of Black men in Prostate Cancer Medical Research: An Original Communication. Submitted to JNMA. July 2011.

•Odedina1, Folakemi T, Dagne2, Getachew, Pressey1, Shannon, Odedina3, Oladapo, Emanuel4, Frank, Scrivens4, John, Reams4, R Renee, Adams5, Angela, LaRose-Pierre4, Margareth. From The Science of Global Prostate Cancer Disparities in Black Men, Jacksonville, FL, USA. 27-29 August 2010. Infectious Agents and Cancer 2011, 6(Suppl 2):S10. http://www.infectagentscancer.com/content/6/S2/S10.

Cancer Related Faculty Patents

Elizabeth Mazzio &. Karam Soliman CIP of #11/711,833
Nutraceutical composition and method of use for treatment / prevention of cancer.

The invention describes a nutraceutical composition and method for preventing/treating cancer comprised of most potent herbs studied in our laboratory: which are suitably combined to inhibit lactic acid dehydrogenase; induce apoptosis, block proliferation of and alkalize the microenvironment, all of which severely incapacitate functional capability of tumor cells. The selected agents in this formula are based on metabolic targeting cancer to minimize chances of tumor cell survival, without adverse effect to the host.

The selected nutraceuticals as described in this embodiment are novel in terms of constituents and design. All of the ingredients in the formula have a large therapeutic index with minimum to no adverse effects on human health.

John Cooperwood, Ph.D

Title of Patent: SERMS FOR THE TREATMENT OF ESTROGEN RECEPTOR-MEDIATED DISORDERS

Patent # : WO/2012/142029
Description: Lead small molecules shown to have activity against both triple negative and estrogen responsive breast cancer cells with little toxicity toward normal breast cells.

Nazarius S. Lamango, Ph.D.,
Professor of Medicinal Chemistry,
College of Pharmacy and Pharmaceutical Sciences

  • US Patent # 8,097,722: Inhibitors of Polyisoprenylated Methylated Protein Methyl Esterase – Compounds.
  • US Patent # 7,897,604: Inhibitors of polyisoprenylated methylated protein methyl esterase – Uses.
  • US Patent # 8,053,207: Cancer Diagnosis by Measuring Polyisoprenylated Methylated Protein Methyl Esterase Activity.

Description: The patents further describe potential targeted therapies designed to specifically inhibit the excessive PMPMEase activities down to normal levels and/or disrupt the polyisoprenylation-dependent protein-protein interactions of hyperactive polyisoprenylated proteins.

K. Ken Redda, Ph.D., Professor and
Interim Vice President for Research

  • Kinfe Redda, Chavonda Janeebra Mills and N. Mateeva, “Synthetic Flavonoids and Pharmaceutical Compositions and Therapeutic Methods of Treatment of HIV Infection and Other Pathologies”, Patent # 8,314,143, issued on November 20, 2012.
  • Kinfe Ken Redda and Madhavi Gangapuram, “N-Aminopyrrolylmethyltetrahydropyridines as Anti-Cancer Agents”, Patent # 8,476,303, issued on July 2, 2013.
  • Kinfe Ken Redda and Madhavi Gangapuram, “N-Aminotetrahydroisoquinolines as Anti-Cancer Agents” Patent Serial No.: 13/307,701, issued on June 24, 2013.

Mandip Sachdeva, Ph.D

  1. Oral Delivery of Modified Multi-layered Microstructures of Active Pharmaceutical Agent(s) by Enhanced Absorption.
    Patent authors: Mandip Singh Sachdeva and Apurva Patel
    Patent number Filed: 13/368,993
  2. Novel Nano-Delivery System for Medical Imaging and Preclinical Imaging
    Patent Filed: 13/851,610
    Patent owners: Mandip Singh Sachdeva and Apurva Patel