Eunsook Lee, RPh, PhD

EDUCATION

• RPh
• PhD

Research Interest

• Project #1: Role of transcription factor yin yang 1 (YY1) in Mn-induced repression of astrocytic
  glutamate transporters (GLAST and GLT-1) and excitotoxic neuronal injury.

• Project #2: Molecular mechanisms of RE1-silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF)-induced protection against Mn toxicity in astrocytes and dopaminergic neurons.

• Project #3: The role of leucine rich repeat kinase 2 (LRRK2) and its genetic variants in Mn-induced neuroinflammation

Selective Publications

• Pajarillo E, Johnson J Jr, Kim J, Karki P, Son DS, Aschner M, Lee E (2018). 17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. NeuroToxicology. 65:280-288. PMID: 29183790.

• Ignacio RMC, Dong YL, Kabir SM, Choi H, Lee ES, Wilson AJ, Beeghly-Fadiel A, Whalen MM, Son DS (2018). CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget. 9(11):9751-9765. PMID: 29515768

• Karki P, Hong P, Johnson J Jr, Pajarillo E, Son DS, Aschner M, Lee EY (2018). Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-κB Pathways. Mol Neurobiol. 55(6):5031-50462017. PMID: 28812276.

• Johnson J Jr, Pajarillo E, Karki P, Kim J, Son DS, Aschner M, Lee E (2018). Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity. Neurotoxicology. 67:112-120. PMID: 29778792.

• Scarton L, Yoon S, Oh S, Agyare E, Trevino J, Han B, Lee E, Setiawan VW, Permuth JB, Schmittgen TD, Odedina FG, Wilkie DJ. Pancreatic Cancer Related Health Disparities: A Commentary. Cancers (Basel). 2018 Jul 18;10(7). PMID: 30021952

• Ignacio RMC, Gibbs CR, Lee ES, Son DS. The TGFα-EGFR-Akt signaling axis plays a role in enhancing proinflammatory chemokines in triple-negative breast cancer cells. Oncotarget. 2018 Jun 29;9(50):29286-29303. PMID: 30034618

• Pratap Karki, James Johnson Jr, Deok-Soo Son, Michael Aschner and Eunsook Lee (2017). Transcriptional regulation of human transforming growth factor-α in astrocytes. Mol Neurobiol. 54(2):964-976. PMID: 26797516.

• Choi H, Ignacio RMC, Lee ES, Wilson AJ, Khabele D, Son DS (2017). Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-κB in Human Serous Ovarian Epithelial Tumors. Immune Network. 17(2):121-127. PMID: 28458624.

• Johnson J Jr, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. (2017). Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. NeuroToxicology. 64:230-239. PMID: 28610743.

• Lee E, Karki P, Johnson J Jr, Hong P, Aschner M (2017). Manganese Control of Glutamate Transporters’ Gene Expression. Adv Neurobiol. 16:1-12. PMID: 28828603.

• Choi H, Ignacio RMC, Lee ES, Roby KF, Terranova PF, Son DS (2017). Localization of Serum Amyloid A3 in the Mouse Ovary. Immune Netw. 17(4):261-268. PMID: 28860955.

• Ignacio RM, Kabir SM, Lee ES, Adunyah SE, Son DS. NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression. PLoS One. 2016;11(10):e0164189. PMID: 27723802

• Rosa Mistica C. Ignacio, Carla R. Gibbs, Lee E, Deok-Soo Son (2016). Differential chemokine signature between human preadipocytes and adipocytes. Immune Network. 16(3):189-94. PMID: 27340388.

• Rosa Mistica C. Ignacio, Syeda M. Kabir, Lee E, Samuel E. Adunyah, Deok-Soo Son (2016). Involvement of NF-B-mediated CCL20 in CXCR2-driven ovarian cancer progression. PLoS One. 11(10): e0164189. PMID: 27723802.