Selina Darling-Reed, Ph.D.

Associate Dean and Associate Professor Pharmaceutical Sciences
LOCATION: East Wing Pharmacy Building Suite # L1-154B
EMAIL: selina.darling@famu.edu
PHONE: 850-412-5078
Biosketch
Selina Darling-Reed, Ph.D., serves as the Associate Professor, Basic Pharmaceutical Sciences, and as the Associate Dean of Pharmaceutical Sciences. Dr. Darling- Reed has extensive experience in cellular and molecular biology and breast cancer research. Her research interests include breast cancer as a health disparity and breast cancer prevention. Her current research using models that use organ sulfide compounds (OSCs; found in garlic) as a chemopreventive agent in induced DNA repair when used as a pre- and co-treatment in breast epithelial cells (MCF-10A) treated with environmental carcinogens (benzo-a-pyrene (BaP). BaP is proven to induce DNA damage in cells, thereby causing mutations that may lead to cancer. In addition, she is interested in breast cancer as a health disparity and the underlying causes of the more aggressive breast cancers diagnosed in African American females at a younger age. Her research interests include breast cancer as a health disparity and breast cancer prevention. Her current research focuses on the study of the repair of DNA damage (using environmental carcinogen the Benzo-a-pyrene via organosulfide compounds (OSCs found in garlic) in-vitro models. Dr. Darling-Reed has extensive experience in mentoring and training research associates, graduate, professional, and undergraduate students. Dr. Darling Reed is currently the core leader of the RCMI Biotechnology Core and Associate Dean of Pharmaceutical Sciences of the COPPS/IPH.

EDUCATION
Research Interest
  • Breast Cancer

  • Health Disparities

  • Environmental Carcinogens and Prevention using Natural products

  • Prostate Cancer

  • Drugs of Abuse

Selective Publications
  • Badisa, R., Wiley, C., Randell, K., Darling-Reed, S., Latinwo, L., Agharahimi, M., Soliman, K. and Goodman, C. Identification of cytotoxic markers in methamphetamine treated rat C6 astroglia-like cells” Sci Rep 2019 Jun 28:9(1): 9412 PMID:31253835

  • Miles, J.., Sojourner SJ, Whitmore, AM, Freeny D, Darling-Reed S., Flores-Rozas, H. Synergistic Effect of Endogenous and Exogenous Aldehydes on Doxorubicin Toxicity in Yeast. Biomed Rs Int. 2018 May 30. PMID: 30003101

  • Miles JS, Sojourner S.J., Jaafer L., Whitmore A., Darling-Reed S., Flores-Rozas H. The Role of Protein Chaperones in the Survival From Anthracycline-Induced Oxidative Stress in Saccharomyces Cerevisiae. Int. J Adv Res (Indore), 2018 Mar; 6(3): 144-152. PMID: 29657945

  • Bauer D, Redmon N, Mazzio E, Taka E, Reuben JS, Day A, Sadrud-Din S, Flores-Rozas H, Soliman KF, Darling-Reed S*. Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-kappa-B signaling. Cytokine. 2015 Sep; 75(1):117-26.

  • Bauer, D. Mazzio, E., Soliman, K.A., Taka, E., Oriaku, E., Womble, T., Darling-Reed, S*. Diallyl Disulfide Inhibits TNFα-induced CCL2 Release by MDA-MB-231 Cells. Anticancer Res. Jun 2014; 34(6): 2763-2770. PMCID: PMC4135704 NIHMSID: NIHMS607606

  • Glass-Holmes M, Aguilar BJ, Gragg RD 3rd, Darling-Reed S., Goodman CB. Characterization of 2-amino-1-methyl-6-phenylimidazo[4,5]pyridine at androgen receptor: mechanistic support for its role in prostate cancer. Am J Cancer Res. 2014 Dec 15;5(1):191-200 PMID 25628930

  • Freeman MD, Mazu T, Miles JS, Darling-Reed S, Flores-Rozas H. Inactivation of chromatin remodeling factors sensitizes cells to selective cytotoxic stress. Biologics 2014 Nov 14; 8:269-80 PMID 25484574

  • Nkrumah-Elie, Y.M., Reuben, J., Hudson, A., Taka, E., Badisa, R., Ardley, T., Israel, B., Sadrud-Din, S.Y., Oriaku, E., Darling-Reed, S.F.* The attenuation of early benzo(a)pyrene-induced carcinogenic insults by diallyl disulfide (DADS) in MCF-10A cell. Nutrition and Cancer:_An international journal 2012 Oct;64(7):1112-21. Epub 2012 Sep 24PMID: 23006051

  • Nkrumah-Elie, Y., Reuben, J.S., Hudson, A., Taka, E., Badisa, R., Ardley, T., Israel, B. Oriaku, E., Darling-Reed, S.F*. Diallyl trisulfide as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A cells. Food and Chemical Toxicology Food ChemToxicol. 2012 Apr 16;50(7):2524-2530. PMID: 22525868

  • Aboyade-Cole, A., Darling-Reed SF, Oriaku E, McCaskill M, Thomas R. (2008) Diallyl Sulfide Inhibits PhIP Induced cell death via inhibition of DNA strand breaks in normal human breast epithelial cells. Oncol Reports. Aug; 20(2):319-23. PMID:17342319